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KMID : 0828519970010010048
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Journal of the Korean Geriatrics Society
1997 Volume.1 No. 1 p.48 ~ p.54
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Proliferation of Cultured Vascular Smooth Muscle Cells(VSMCs) Obtained from Aortas of Insulin Dependent Diabetic Rats
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Yoo Hyung-Joon
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Abstract
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Background : Vascular smooth muscle cells(VSMCs) from diabetic animals proliferate more than that from non-diabetic ones. The proliferative ability of cultured VSMCs is changed by the kind of experimental animals, experimental technique and so on. In this study, I used VSMCs from streptozotocin-induced insulin dependent diabetic Sprague Dawley rats and examined the characteristics of aortic VSMCs proliferation from these rats.
Methods : Using enzyme method I cultured aortic VSMCs. I compared the proliferation between normal rat VSMCs and diabetic ones. I studied the cell growth of VSMCs from diabetic rats as a function of period after streptozotocin injection. I also examined the effects of hyperglycemia and insulin treatment on the proliferation of cultured VSMCs.
Results : Diabetic rats VSMCs proliferated more than non-diabetic ones in streptozotocin-induced insulin dependent diabetic rats. The proliferation of VSMCs was enhanced from 2 weeks after streptozotocin injection. Hyperglycemia enhanced the proliferation and insulin treatment lowered that.
Conclusions : The proliferation of VSMCs was increased in streptozotocin-induced diabetic rats.
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KEYWORD
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Diabetic rat, Streptozotocin, Vascular smooth muscle cell, Proliferati
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